The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Pulmonary fibrosis (not otherwise specified or unclassifiable)
Publications
Interstitial pulmonary fibrosis following busulfan therapy.
The American journal of medicine 1961 Jul;31;134-9 — 1961 Jul — 134-9
Possible pulmonary effects of alkylating agents.
The New England journal of medicine 1972 Nov 30;287;1150-1 — 1972 Nov 30 — 1150-1