The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVII.a

BAL: An excess proportion of lymphocytes

Publications

D'Elia T

Methotrexate-induced pneumonitis: heterogeneity of bronchoalveolar lavage and differences between cancer and rheumatoid arthritis.

Inflammation & allergy drug targets 2014 Feb;13;25-33 — 2014 Feb — 25-33

Schnabel A, Richter C, Bauerfeind S, Gross WL

Bronchoalveolar lavage cell profile in methotrexate induced pneumonitis.

Thorax 1997 Apr;52;377-9 — 1997 Apr — 377-9

White DA, Rankin JA, Stover DE, Gellene RA, Gupta S

Methotrexate pneumonitis. Bronchoalveolar lavage findings suggest an immunologic disorder.

The American review of respiratory disease 1989 Jan;139;18-21 — 1989 Jan — 18-21