The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVIII.l

Path: Giant-cell interstitial pneumonia (GIP)-pattern

Publications

Khoor A, Roden AC, Colby TV, Roggli VL, Elrefaei M, Alvarez F, Erasmus DB, Mallea JM, Murray DL, Keller CA

Giant cell interstitial pneumonia in patients without hard metal exposure: analysis of 3 cases and review of the literature.

Human pathology 2016 Apr;50;176-82 — 2016 Apr — 176-82

Hargett CW, Sporn TA, Roggli VL, Hollingsworth JW

Giant cell interstitial pneumonia associated with nitrofurantoin.

Lung 2006 May-Jun;184;147-9 — 2006 May-Jun — 147-9

Magee F, Wright JL, Chan N, Currie W, Karr G, Hogg J, Thurlbeck WM

Two unusual pathological reactions to nitrofurantoin: case reports.

Histopathology 1986 Jul;10;701-6 — 1986 Jul — 701-6