The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVIII.d

Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

Publications

Martins RS, Machado JA, Teixeira R

Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a.

Revista da Sociedade Brasileira de Medicina Tropical 2012 Oct;45;655-6 — 2012 Oct — 655-6

Kumar KS, Russo MW, Borczuk AC, Brown M, Esposito SP, Lobritto SJ, Jacobson IM, Brown RS

Significant pulmonary toxicity associated with interferon and ribavirin therapy for hepatitis C.

The American journal of gastroenterology 2002 Sep;97;2432-40 — 2002 Sep — 2432-40

Ogata K, Koga T, Yagawa K

Interferon-related bronchiolitis obliterans organizing pneumonia.

Chest 1994 Aug;106;612-3 — 1994 Aug — 612-3