The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Imaging: Centrilobular micronodules (can be diffuse)
Publications
Centrilobular ground-glass nodule pattern in acute myeloid leukemia patients receiving cytosine arabinoside chemotherapy: an important form of drug-induced lung disease.
Diagnostic and interventional radiology (Ankara, Turkey) 2023 May 03;; — 2023 May 03
A new pattern of cytosine-arabinoside-induced lung toxicity.
British journal of haematology 2009 Dec;147;771-4 — 2009 Dec — 771-4