The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

Publications

Mullerpattan JB, Dagaonkar RS, Shah HD, Udwadia ZF

Fatal nitrofurantoin lung.

The Journal of the Association of Physicians of India. 2013;61(10):758-60

Viejo MA, Fernández Montes A, Montes JV, Gómez-Román JJ, Ibarbia CG, Hernández JL

[Rapid resolution of nitrofurantoin-induced interstitial lung disease].

Archivos de bronconeumologia. 2009;45(7):352-5

Mohamed A, Dresser GK, Mehta S

Acute respiratory failure during pregnancy: a case of nitrofurantoin-induced pneumonitis.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2007;176(3):319-20

Holmberg L, Boman G, Böttiger LE, Eriksson B, Spross R, Wessling A

Adverse reactions to nitrofurantoin. Analysis of 921 reports.

The American journal of medicine. 1980;69(5):733-8

Jick SS, Jick H, Walker AM, Hunter JR

Hospitalizations for pulmonary reactions following nitrofurantoin use.

Chest. 1989;96(3):512-5