The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Mullerpattan JB, Dagaonkar RS, Shah HD, Udwadia ZF

Fatal nitrofurantoin lung.

The Journal of the Association of Physicians of India 2013 Oct;61;758-60 — 2013 Oct — 758-60

Viejo MA, Fernández Montes A, Montes JV, Gómez-Román JJ, Ibarbia CG, Hernández JL

[Rapid resolution of nitrofurantoin-induced interstitial lung disease].

Archivos de bronconeumologia 2009 Jul;45;352-5 — 2009 Jul — 352-5

Mohamed A, Dresser GK, Mehta S

Acute respiratory failure during pregnancy: a case of nitrofurantoin-induced pneumonitis.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2007 Jan 30;176;319-20 — 2007 Jan 30 — 319-20

Holmberg L, Boman G, Böttiger LE, Eriksson B, Spross R, Wessling A

Adverse reactions to nitrofurantoin. Analysis of 921 reports.

The American journal of medicine 1980 Nov;69;733-8 — 1980 Nov — 733-8

Jick SS, Jick H, Walker AM, Hunter JR

Hospitalizations for pulmonary reactions following nitrofurantoin use.

Chest 1989 Sep;96;512-5 — 1989 Sep — 512-5