The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

See also: http://journal.chestnet.org/article/S0012-3692(17)32382-6/fulltext; http://dx.doi.org/10.1016/j.chest.2017.08.864; http://www.limbrel.com/downloads/post_mkt_surv.pdf

Publications

Drekolias D, Gadela NV, Krupka P, Broess J, Jacob J

A Rare Case of Flavocoxid-Induced Pulmonary Fibrosis.

Cureus 2020 Aug 08;12;e9617 — 2020 Aug 08 — e9617

Panduranga V, Atienza J, Kumar A, Metersky ML

Hypersensitivity pneumonitis due to flavocoxid: are corticosteroids necessary?

Connecticut medicine 2013 Feb;77;87-90 — 2013 Feb — 87-90

Levy RM

Flavocoxid and hypersensitivity pneumonitis.

Chest 2011 Sep;140;827-828 — 2011 Sep — 827-828