The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LIII.a

Methemoglobinemia

Publications

Rizvi I, Zaman S, Zaidi N, Asif MS, Abdali N

Acute life-threatening methaemoglobinaemia following ingestion of chloroquine.

BMJ case reports 2012 Mar 20;2012; — 2012 Mar 20

Sankar J, Gupta A, Pathak S, Dubey NK

Death in an adolescent girl with methemoglobinemia and malaria.

Journal of tropical pediatrics 2012 Apr;58;154-6 — 2012 Apr — 154-6

Cohen RJ, Sachs JR, Wicker DJ, Conrad ME

Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam.

The New England journal of medicine 1968 Nov 21;279;1127-31 — 1968 Nov 21 — 1127-31