The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pneumocystis jiroveci pneumonia
Publications
Pneumocystis jirovecii infection: an emerging threat to patients with rheumatoid arthritis.
Rheumatology (Oxford, England) 2012 Dec;51;2120-30 — 2012 Dec — 2120-30
Tanaka M, Sakai R, Koike R, Komano Y, Nanki T, Sakai F, Sugiyama H, Matsushima H, Kojima T, Ohta S, Ishibe Y, Sawabe T, Ota Y, Ohishi K, Miyazato H, Nonomura Y, Saito K, Tanaka Y, Nagasawa H, Takeuchi T, Nakajima A, Ohtsubo H, Onishi M, Goto Y, Dobashi H,
Pneumocystis jirovecii pneumonia associated with etanercept treatment in patients with rheumatoid arthritis: a retrospective review of 15 cases and analysis of risk factors.
Modern rheumatology 2012 Nov;22;849-58 — 2012 Nov — 849-58
Pulmonary coinfection by Pneumocystis carinii and Aspegillus fumigatus in a seronegative arthritis patient treated with low-dose methotrexate.
Clinical rheumatology 2004 Dec;23;555-6 — 2004 Dec — 555-6
Severe pneumonitis occurring during methotrexate therapy. Re- port of two cases.
Archives of dermatology 1971 Feb;103;194-7 — 1971 Feb — 194-7
Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma.
Thorax 1991 Dec;46;936-7 — 1991 Dec — 936-7