The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

McCormick J, Cole S, Lahirir B, Knauft F, Cohen S, Yoshida T

Pneumonitis caused by gold salt therapy: evidence for the role of cell-mediated immunity in its pathogenesis.

The American review of respiratory disease 1980 Jul;122;145-52 — 1980 Jul — 145-52

Ettensohn DB, Roberts NJ, Condemi JJ

Bronchoalveolar lavage in gold lung.

Chest 1984 Apr;85;569-70 — 1984 Apr — 569-70