The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Causality unclear when drug given along with chemo agents (e.g. PMID 30739089)

Publications

Rezkallah KNM, Ahmed A, Patel S, Kozma K

A case of panitumumab containing chemotherapy causing interstitial lung disease: early recognition and treatment resulting in a good outcome.

BMJ case reports. 2019;12(2)

Osawa M, Kudoh S, Sakai F, Endo M, Hamaguchi T, Ogino Y, Yoneoka M, Sakaguchi M, Nishimoto H, Gemma A

Clinical features and risk factors of panitumumab-induced interstitial lung disease: a postmarketing all-case surveillance study.

International journal of clinical oncology. 2015;20(6):1063-71

Sugaya A, Moriwaki T, Tajima D, Imanishi M, Hamano Y, Kobayashi M, Akutsu D, Kobayashi K, Ochi D, Yamada T, Yamamoto Y, Endo S, Suzuki H, Hyodo I

[A retrospective analysis of cetuximab or panitumumab monotherapy for KRAS wild-type metastatic colorectal cancer in clinical practice].

Gan to kagaku ryoho. Cancer & chemotherapy. 2015;42(2):189-93

Boku N, Sugihara K, Kitagawa Y, Hatake K, Gemma A, Yamazaki N, Muro K, Hamaguchi T, Yoshino T, Yana I, Ueno H, Ohtsu A

Panitumumab in Japanese patients with unresectable colorectal cancer: a post-marketing surveillance study of 3085 patients.

Japanese journal of clinical oncology. 2014;44(3):214-23

Yamada T, Moriwaki T, Matsuda K, Yamamoto Y, Sugaya A, Akutsu D, Murashita T, Endo S, Hyodo I

Panitumumab-induced interstitial lung disease in a case of metastatic colorectal cancer.

Onkologie. 2013;36(4):209-12