The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.a

Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

Publications

Vale A

Organophosphorus insecticide poisoning.

BMJ clinical evidence. 2015;2015

Hulse EJ, Davies JO, Simpson AJ, Sciuto AM, Eddleston M

Respiratory complications of organophosphorus nerve agent and insecticide poisoning. Implications for respiratory and critical care.

American journal of respiratory and critical care medicine. 2014;190(12):1342-54

Carey JL, Dunn C, Gaspari RJ

Central respiratory failure during acute organophosphate poisoning.

Respiratory physiology & neurobiology. 2013;189(2):403-10

Eddleston M, Mohamed F, Davies JO, Eyer P, Worek F, Sheriff MH, Buckley NA

Respiratory failure in acute organophosphorus pesticide self-poisoning.

QJM : monthly journal of the Association of Physicians. 2006;99(8):513-22