The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.b

Bronchospasm and angioedema

Publications

Kuku I, Kaya E, Sevinc A, Aydogdu I

Gemcitabine-induced erysipeloid skin lesions in a patient with malignant mesothelioma.

Journal of the European Academy of Dermatology and Venereology : JEADV. 2002;16(3):271-2

Sørensen JB, Bergman B, Nielsen AL, Krarup M, Dombernowsky P, Hansen HH

Phase II study of gemcitabine and vindesine in patients with previously untreated non-resectable non-small-cell lung cancer.

British journal of cancer. 1999;79(5-6):875-81