The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.f

ARDS and the hemolytic-uremic syndrome (HUS)

Publications

Moya-Horno I, Querol Niñerola R, Bonfill Abella T, Dalmau Pórtulas E, Gallardo-Díaz E, Saigí Grau E, Pericay Pijaume C

Haemolytic uraemic syndrome associated with gemcitabine.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2010 May;12;381-3 — 2010 May — 381-3

Desramé J, Duvic C, Bredin C, Béchade D, Artru P, Brézault C, Defuentes G, Poirier JM, Dourthe LM, Coutant G, Chaussade S, de Gramont A, Algayres JP

[Hemolytic uremic syndrome as a complication of gemcitabine treatment: report of six cases and review of the literature].

La Revue de medecine interne 2005 Mar;26;179-88 — 2005 Mar — 179-88

Rabinowits G, Herchenhorn D, Rabinowits M, Weatge D, Torres W

Fatal pulmonary toxicity in a patient treated with gefitinib for non-small cell lung cancer after previous hemolytic-uremic syndrome due to gemcitabine.

Anti-cancer drugs 2003 Sep;14;665-8 — 2003 Sep — 665-8

Walter RB, Joerger M, Pestalozzi BC

Gemcitabine-associated hemolytic-uremic syndrome.

American journal of kidney diseases : the official journal of the National Kidney Foundation 2002 Oct;40;E16 — 2002 Oct — E16

Carron PL, Cousin L, Caps T, Belle E, Pernet D, Neidhardt A, Capellier G

Gemcitabine-associated diffuse alveolar hemorrhage.

Intensive care medicine 2001 Sep;27;1554 — 2001 Sep — 1554

Fung MC, Storniolo AM, Nguyen B, Arning M, Brookfield W, Vigil J

A review of hemolytic uremic syndrome in patients treated with gemcitabine therapy.

Cancer 1999 May 01;85;2023-32 — 1999 May 01 — 2023-32