The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LIII.a

Methemoglobinemia

Publications

Badii F, Maghelli S, Costa N, Borreggine D, Zoccali G, Durì D

Acute methemoglobinemia after nitroglycerine transcutaneous absorption after bomb explosion: a case report.

The Journal of trauma 2009 Mar;66;936-7 — 2009 Mar — 936-7

Williams RS, Mickell JJ, Young ES, Shapiro JH, Lofland GK

Methemoglobin levels during prolonged combined nitroglycerin and sodium nitroprusside infusions in infants after cardiac surgery.

Journal of cardiothoracic and vascular anesthesia 1994 Dec;8;658-62 — 1994 Dec — 658-62