The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIV.a

Methemoglobinemia

PMID 33727299

Publications

Surya N, Wu CH, Ryan H

Rasburicase-induced methemoglobinemia and haemolytic anaemia in a patient with G6PD deficiency.

BMJ case reports. 2025;18(3)

Madanat L, Schoenherr D, Wey E, Gupta R

Rasburicase-induced haemolysis and methemoglobinemia: an ongoing issue.

BMJ case reports. 2021;14(3)

Marinacci LX, Simeone FJ, Lundquist AL, Kuter DJ, Mahowald GK

Case 38-2020: A 52-Year-Old Man with Cancer and Acute Hypoxemia.

The New England journal of medicine. 2020;383(24):2372-2383

Raru Y, Abouzid M, Parsons J, Zeid F

Rasburicase induced severe hemolysis and methemoglobinemia in a Caucasian patient complicated by acute renal failure and ARDS.

Respiratory medicine case reports. 2019;26:142-145

Ibrahim U, Saqib A, Mohammad F, Atallah JP, Odaimi M

Rasburicase-induced methemoglobinemia: The eyes do not see what the mind does not know.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2018;24(4):309-313

Bontant T, Le Garrec S, Avran D, Dauger S

Methaemoglobinaemia in a G6PD-deficient child treated with rasburicase.

BMJ case reports. 2014;2014

Bucklin MH, Groth CM

Mortality following rasburicase-induced methemoglobinemia.

The Annals of pharmacotherapy. 2013;47(10):1353-8

Bauters T, Mondelaers V, Robays H, De Wilde H, Benoit Y, De Moerloose B

Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia.

International journal of clinical pharmacy. 2011;33(1):58-60

Browning LA, Kruse JA

Hemolysis and methemoglobinemia secondary to rasburicase administration.

The Annals of pharmacotherapy. 2005;39(11):1932-5