The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD)

Publications

San José Ruiz B, Molas Ferrer G, Castro Rebollo P, Soy Muner D

[Interstitial pneumonitis due to gemcitabine].

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 2012 Sep-Oct;36;452-3 — 2012 Sep-Oct — 452-3

Umemura S, Yamane H, Suwaki T, Katoh T, Yano T, Shiote Y, Takigawa N, Kiura K, Kamei H

Interstitial lung disease associated with gemcitabine treatment in patients with non-small-cell lung cancer and pancreatic cancer.

Journal of cancer research and clinical oncology 2011 Oct;137;1469-75 — 2011 Oct — 1469-75

Joerger M, Gunz A, Speich R, Pestalozzi BC

Gemcitabine-related pulmonary toxicity.

Swiss medical weekly 2002 Jan 12;132;17-20 — 2002 Jan 12 — 17-20

Rosado MF, Kett DH, Schein RM, Baraona FJ, Sridhar KS

Severe pulmonary toxicity in a patient treated with gemcitabine.

American journal of clinical oncology 2002 Feb;25;31-3 — 2002 Feb — 31-3

Chen YM, Perng RP, Yang KY, Liu TW, Tsai CM, Ming-Liu J, Whang-Peng J

A multicenter phase II trial of vinorelbine plus gemcitabine in previously untreated inoperable (Stage IIIB/IV) non-small cell lung cancer.

Chest 2000 Jun;117;1583-9 — 2000 Jun — 1583-9

Pavlakis N, Bell DR, Millward MJ, Levi JA

Fatal pulmonary toxicity resulting from treatment with gemcitabine.

Cancer 1997 Jul 15;80;286-91 — 1997 Jul 15 — 286-91