The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVIII.a

Path: NSIP-cellular pattern (see also Ia, Ib)

Publications

Nomani AZ, Qureshi MS, Barki UF, Wazir M, Kashmir SB, Nomani H

Pegylated-interferon induced interstitial pneumonitis.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2014 Mar;24;219-20 — 2014 Mar — 219-20

Abi-Nassif S, Mark EJ, Fogel RB, Hallisey RK

Pegylated interferon and ribavirin-induced interstitial pneumonitis with ARDS.

Chest 2003 Jul;124;406-10 — 2003 Jul — 406-10

Kumar KS, Russo MW, Borczuk AC, Brown M, Esposito SP, Lobritto SJ, Jacobson IM, Brown RS

Significant pulmonary toxicity associated with interferon and ribavirin therapy for hepatitis C.

The American journal of gastroenterology 2002 Sep;97;2432-40 — 2002 Sep — 2432-40