The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.c

Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

Publications

Hashimoto I, Imaizumi K, Hashimoto N, Furukawa H, Noda Y, Kawabe T, Honda T, Ogawa T, Matsuo M, Imai N, Ito S, Sato M, Kondo M, Shimokata K, Hasegawa Y

Aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans.

Respirology (Carlton, Vic.). 2013;18(2):340-7

Epler GR

Constrictive bronchiolitis obliterans: the fibrotic airway disorder.

Expert review of respiratory medicine. 2007;1(1):139-47

Oonakahara K, Matsuyama W, Higashimoto I, Machida K, Kawabata M, Arimura K, Osame M, Hayashi M, Ogura T, Imaizumi K, Hasegawa Y

Outbreak of Bronchiolitis obliterans associated with consumption of Sauropus androgynus in Japan--alert of food-associated pulmonary disorders from Japan.

Respiration; international review of thoracic diseases. 2005;72(2):221

Chang YL, Chen JS, Wu HD, Lee YC

Retransplantation of contralateral lung in a patient with Sauropus androgynus-induced bronchobronchiolitis obliterans.

Transplantation proceedings. 2000;32(7):2432-4

Kao CH, Ho YJ, Wu CL, ChangLai SP

Using 99mTc-DTPA radioaerosol inhalation lung scintigraphies to detect the lung injury induced by consuming Sauropus androgynus vegetable and comparison with conventional pulmonary function tests.

Respiration; international review of thoracic diseases. 1999;66(1):46-51

Chang YL, Yao YT, Wang NS, Lee YC

Segmental necrosis of small bronchi after prolonged intakes of Sauropus androgynus in Taiwan.

American journal of respiratory and critical care medicine. 1998;157(2):594-8

Hsiue TR, Guo YL, Chen KW, Chen CW, Lee CH, Chang HY

Dose-response relationship and irreversible obstructive ventilatory defect in patients with consumption of Sauropus androgynus.

Chest. 1998;113(1):71-6

Higenbottam TW

Bronchiolitis obliterans following the ingestion of an Asian shrub leaf.

Thorax. 1997;52 Suppl 3(Suppl 3):S68-72

Ger LP, Chiang AA, Lai RS, Chen SM, Tseng CJ

Association of Sauropus androgynus and bronchiolitis obliterans syndrome: a hospital-based case-control study.

American journal of epidemiology. 1997;145(9):842-9

Yang CF, Wu MT, Chiang AA, Lai RS, Chen C, Tiao WM, McLoud TC, Wang JS, Pan HB

Correlation of high-resolution CT and pulmonary function in bronchiolitis obliterans: a study based on 24 patients associated with consumption of Sauropus androgynus.

AJR. American journal of roentgenology. 1997;168(4):1045-50

Chang H, Wang JS, Tseng HH, Lai RS, Su JM

Histopathological study of Sauropus androgynus-associated constrictive bronchiolitis obliterans: a new cause of constrictive bronchiolitis obliterans.

The American journal of surgical pathology. 1997;21(1):35-42

Lai RS, Chiang AA, Wu MT, Wang JS, Lai NS, Lu JY, Ger LP, Roggli V

Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan.

Lancet (London, England). 1996;348(9020):83-5

Lin TJ, Lu CC, Chen KW, Deng JF

Outbreak of obstructive ventilatory impairment associated with consumption of Sauropus androgynus vegetable.

Journal of toxicology. Clinical toxicology. 1996;34(1):1-8