The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.a

DRES syndrome - DRESS-like reaction

Publications

Pinto B, Dhir V, Krishnan S, Nada R

Leflunomide-induced DRESS syndrome with renal involvement and vasculitis.

Clinical rheumatology 2013 May;32;689-93 — 2013 May — 689-93

Vaish AK, Tripathi AK, Gupta LK, Jain N, Agarwal A, Verma SK

An unusual case of DRESS syndrome due to leflunomide.

BMJ case reports 2011 Sep 04;2011; — 2011 Sep 04

Mohty R, Chaby G, Pannier M, Defossez C, Denoeux JP, Lok C

[Drug hypersensitivity syndrome induced by leflunomide].

Annales de dermatologie et de venereologie 2003 May;130;551-2 — 2003 May — 551-2