The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.e

Path: ILD with a granulomatous component (see also Im)

Publications

Sakata KK, Larsen BT, Boland JM, Palen B, Muhm JR Sr, Helmers RA, Tazelaar HD

Nitrofurantoin-Induced Granulomatous Interstitial Pneumonia.

International journal of surgical pathology. 2014;22(4):352-7

Cilloniz R, Chesrown SE, Gonzalez-Peralta RP

Asymptomatic presentation of mesalamine-induced lung injury in an adolescent with Crohn disease.

BMJ case reports. 2009;2009

Magee F, Wright JL, Chan N, Currie W, Karr G, Hogg J, Thurlbeck WM

Two unusual pathological reactions to nitrofurantoin: case reports.

Histopathology. 1986;10(7):701-6