The Drug-Induced Respiratory Disease Website and App

BCG therapy (topical instillations in the urinary bladder)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LIX.i

Mycobacterium bovis/BCG infection

Risk increases in naturally or iatrogenically immunosuppressed individuals (PMID 12856232)

Publications

Spisarova M, Losse S, Jakubec P, Hartmann I, Kral M, Ehrmann J, Szkorupa M, Studentova H, Melichar B

Bacillus Calmette-Guérin pneumonitis after intravesical instillation: Report of two cases and a review of the literature.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2023 Jan 02;; — 2023 Jan 02

Cho JL, McDermott S, Tsibris AM, Mark EJ

CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 37-2015. A 76-Year-Old Man with Fevers, Leukopenia, and Pulmonary Infiltrates.

The New England journal of medicine 2015 Nov 26;373;2162-72 — 2015 Nov 26 — 2162-72

Mahmoudi S, Khaheshi S, Pourakbari B, Aghamohammadi A, Keshavarz Valian S, Bahador A, Sabouni F, Ramezani A, Mamishi S

Adverse reactions to Mycobacterium bovis bacille Calmette-Guérin vaccination against tuberculosis in Iranian children.

Clinical and experimental vaccine research 2015 Jul;4;195-9 — 2015 Jul — 195-9

Pommier JD, Ben Lasfar N, Van Grunderbeeck N, Burdet C, Laouénan C, Rioux C, Pierre-Audigier C, Meybeck A, Choudat L, Benchikh A, Nguyen S, Bouvet E, Yeni P, Yazdanpanah Y, Joly V

Complications following intravesical bacillus Calmette-Guerin treatment for bladder cancer: a case series of 22 patients.

Infectious diseases (London, England) 2015;47;725-31 — 2015 — 725-31

Iqbal J, Raja M, Leung J

Peritoneal tuberculosis presenting as recurrent peritonitis secondary to treatment with intravesical Bacillus Calmette-Guérin in a patient receiving peritoneal dialysis.

Clinical kidney journal 2015 Feb;8;107-8 — 2015 Feb — 107-8

Pérez-Jacoiste Asín MA, Fernández-Ruiz M, López-Medrano F, Lumbreras C, Tejido A, San Juan R, Arrebola-Pajares A, Lizasoain M, Prieto S, Aguado JM

Bacillus Calmette-Guérin (BCG) infection following intravesical BCG administration as adjunctive therapy for bladder cancer: incidence, risk factors, and outcome in a single-institution series and review of the literature.

Medicine 2014 Oct;93;236-54 — 2014 Oct — 236-54

Linden-Castro E, Pelayo-Nieto M, Alias-Melgar A

Penile tuberculosis after intravesical bacille Calmette-Guérin immunotherapy.

Urology 2014 Aug;84;e3 — 2014 Aug — e3

Bacalhau S, Freitas C, Valente R, Barata D, Neves C, Schäfer K, Lubatschofski A, Schulz A, Neves JF

Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency.

Case reports in medicine 2011;2011;527569 — 2011 — 527569

Akbulut Z, Canda AE, Atmaca AF, Cimen HI, Hasanoglu C, Balbay MD

BCG sepsis following inadvertent intravenous BCG administration for the treatment of bladder cancer can be effectively cured with anti-tuberculosis medications.

The New Zealand medical journal 2010 Nov 05;123;72-7 — 2010 Nov 05 — 72-7

Abad S, Gyan E, Moachon L, Bouscary D, Sicard D, Dreyfus F, Blanche P

Tuberculosis due to Mycobacterium bovis after alemtuzumab administration.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2003 Jul 15;37;e27-8 — 2003 Jul 15 — e27-8

Iantorno R, Nicolai M, Storto ML, Ciccotosto C, Cipollone G, Mastroprimiano G, Tenaglia RL

Miliary tuberculosis of the lung in a patient treated with bacillus Calmette-Guerin for superficial bladder cancer.

The Journal of urology 1998 May;159;1639-40 — 1998 May — 1639-40

Kristjansson M, Green P, Manning HL, Slutsky AM, Brecher SM, von Reyn CF, Arbeit RD, Maslow JN

Molecular confirmation of bacillus Calmette-Guérin as the cause of pulmonary infection following urinary tract instillation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1993 Aug;17;228-30 — 1993 Aug — 228-30

Sicard D, Steg A, Leleu C, Boccaccio F, Abadia R, Tulliez M, Cremer GA

["BCGitis", a systemic complication of intravesical BCG therapy of bladder tumor].

Annales de medecine interne 1987;138;555-6 — 1987 — 555-6

Ritch PS, McCredie KB, Gutterman JU, Hersh EM

Disseminated BCG disease associated with immunotherapy by scarification in acute leukemia.

Cancer 1978 Jul;42;167-70 — 1978 Jul — 167-70