The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Mycobacterium bovis/BCG infection
Risk increases in naturally or iatrogenically immunosuppressed individuals (PMID 12856232)
Publications
Spisarova M, Losse S, Jakubec P, Hartmann I, Kral M, Ehrmann J, Szkorupa M, Studentova H, Melichar B
Bacillus Calmette-Guérin pneumonitis after intravesical instillation: Report of two cases and a review of the literature.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2024;168(2):181-186
CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 37-2015. A 76-Year-Old Man with Fevers, Leukopenia, and Pulmonary Infiltrates.
The New England journal of medicine. 2015;373(22):2162-72
Mahmoudi S, Khaheshi S, Pourakbari B, Aghamohammadi A, Keshavarz Valian S, Bahador A, Sabouni F, Ramezani A, Mamishi S
Adverse reactions to Mycobacterium bovis bacille Calmette-Guérin vaccination against tuberculosis in Iranian children.
Clinical and experimental vaccine research. 2015;4(2):195-9
Pommier JD, Ben Lasfar N, Van Grunderbeeck N, Burdet C, Laouénan C, Rioux C, Pierre-Audigier C, Meybeck A, Choudat L, Benchikh A, Nguyen S, Bouvet E, Yeni P, Yazdanpanah Y, Joly V
Complications following intravesical bacillus Calmette-Guerin treatment for bladder cancer: a case series of 22 patients.
Infectious diseases (London, England). 2015;47(10):725-31
Peritoneal tuberculosis presenting as recurrent peritonitis secondary to treatment with intravesical Bacillus Calmette-Guérin in a patient receiving peritoneal dialysis.
Clinical kidney journal. 2015;8(1):107-8
Pérez-Jacoiste Asín MA, Fernández-Ruiz M, López-Medrano F, Lumbreras C, Tejido Á, San Juan R, Arrebola-Pajares A, Lizasoain M, Prieto S, Aguado JM
Bacillus Calmette-Guérin (BCG) infection following intravesical BCG administration as adjunctive therapy for bladder cancer: incidence, risk factors, and outcome in a single-institution series and review of the literature.
Medicine. 2014;93(17):236-254
Penile tuberculosis after intravesical bacille Calmette-Guérin immunotherapy.
Urology. 2014;84(2):e3
Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency.
Case reports in medicine. 2011;2011:527569
BCG sepsis following inadvertent intravenous BCG administration for the treatment of bladder cancer can be effectively cured with anti-tuberculosis medications.
The New Zealand medical journal. 2010;123(1325):72-7
Tuberculosis due to Mycobacterium bovis after alemtuzumab administration.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2003;37(2):e27-8
Miliary tuberculosis of the lung in a patient treated with bacillus Calmette-Guerin for superficial bladder cancer.
The Journal of urology. 1998;159(5):1639-40
Molecular confirmation of bacillus Calmette-Guérin as the cause of pulmonary infection following urinary tract instillation.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 1993;17(2):228-30
["BCGitis", a systemic complication of intravesical BCG therapy of bladder tumor].
Annales de medecine interne. 1987;138(7):555-6
Disseminated BCG disease associated with immunotherapy by scarification in acute leukemia.
Cancer. 1978;42(1):167-70