The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

L.o

Death following exposure or poisoning

Publications

Bishop-Freeman SC, Friederich LW, Feaster MS, Hudson JS

Buprenorphine-Related Deaths in North Carolina from 2010-2018.

Journal of analytical toxicology 2021 Jun 19;; — 2021 Jun 19

Kim HK, Smiddy M, Hoffman RS, Nelson LS

Buprenorphine may not be as safe as you think: a pediatric fatality from unintentional exposure.

Pediatrics 2012 Dec;130;e1700-3 — 2012 Dec — e1700-3