The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Chest pain (acute or subacute), lone or prominent
Statins can induce acute relapsing lone chest pain simulating pleuritic chest pain or AMI. Occasionnally, chest pain develops in association with statin-induced ILD (PMID 11547251, 16788504)
Publications
Chest pain as a possible side effect of pitavastatin (Livalo).
Journal of family & community medicine 2019 Jan-Apr;26;61-63 — 2019 Jan-Apr — 61-63
Bronchiolitis obliterans organizing pneumonia. Clinical and roentgenological features in 26 cases.
Respiration; international review of thoracic diseases 2005 May-Jun;72;254-62 — 2005 May-Jun — 254-62