The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVIII.o

Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

Publications

Martos VP, Vonlanthen B

[Fatal pneumonitis during low-dose methotrexate treatment].

Zeitschrift fur Rheumatologie 2012 Jan;71;75-7 — 2012 Jan — 75-7

Dai MS, Ho CL, Chen YC, Kao WY, Chao TY

Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature.

Annals of hematology 2000 Dec;79;696-9 — 2000 Dec — 696-9

Imokawa S, Colby TV, Leslie KO, Helmers RA

Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients.

The European respiratory journal 2000 Feb;15;373-81 — 2000 Feb — 373-81

Bhat KS, Anderson KR, Stewart RD

Lung disease associated with methotrexate therapy.

Australian and New Zealand journal of medicine 1974 Jun;4;277-80 — 1974 Jun — 277-80

Lisbona A, Schwartz J, Lachance C, Frank H, Palayew MJ

Methotrexate-induced pulmonary disease.

Journal of the Canadian Association of Radiologists 1973 Sep;24;215-20 — 1973 Sep — 215-20