The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)
Publications
Comment on methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis.
Arthritis and rheumatism 2003 Aug 15;49;617; author reply 617-8 — 2003 Aug 15 — 617; author reply 617-8
Fatal pulmonary fibrosis complicating low dose methotrexate therapy for rheumatoid arthritis.
The Journal of rheumatology 1995 Sep;22;1766-8 — 1995 Sep — 1766-8