The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LIII.a

Methemoglobinemia

Publications

De Crem N, Verleden GM, Godinas L, Vos R

Once in a blue moon: Primaquine-induced methemoglobinemia - A case report.

Respiratory medicine case reports 2022;38;101675 — 2022 — 101675

Ferreira ME, Gomes Mdo S, Vieira JL

[Methemoglobinemia in patients with Plasmodium vivax receiving oral therapy with primaquine].

Revista da Sociedade Brasileira de Medicina Tropical 2011 Jan-Feb;44;113-5 — 2011 Jan-Feb — 113-5

HANSEN JE, CLEVE EA, PRUITT FW

Relapse of vivax malaria treated with primaquine and report of one case of cyanosis (methemoglobinemia) due to primaquine.

The American journal of the medical sciences 1954 Jan;227;9-12 — 1954 Jan — 9-12

Baird JK, Lacy MD, Basri H, Barcus MJ, Maguire JD, Bangs MJ, Gramzinski R, Sismadi P, Krisin , Ling J, Wiady I, Kusumaningsih M, Jones TR, Fryauff DJ, Hoffman SL,

Randomized, parallel placebo-controlled trial of primaquine for malaria prophylaxis in Papua, Indonesia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001 Dec 15;33;1990-7 — 2001 Dec 15 — 1990-7

Safrin S, Finkelstein DM, Feinberg J, Frame P, Simpson G, Wu A, Cheung T, Soeiro R, Hojczyk P, Black JR

Comparison of three regimens for treatment of mild to moderate Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim, and clindamycin-primaquine. ACTG 108 Study

Annals of internal medicine 1996 May 01;124;792-802 — 1996 May 01 — 792-802

Cohen RJ, Sachs JR, Wicker DJ, Conrad ME

Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam.

The New England journal of medicine 1968 Nov 21;279;1127-31 — 1968 Nov 21 — 1127-31