The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.s

Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

Publications

Agur T, Levy Y, Plotkin E, Benchetrit S

Minocycline-induced polyarteritis nodosa-like vasculitis.

The Israel Medical Association journal : IMAJ. 2014;16(5):322-3

Lyon TD, Ferroni MC, Casella DP, D'Agostino LA, Jackman SV

Segmental testicular infarction due to minocycline-induced antineutrophil cytoplasmic antibody--positive vasculitis.

Urology. 2014;84(1):e1-2

Pendergraft WF 3rd, Niles JL

Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.

Current opinion in rheumatology. 2014;26(1):42-9

Lenert P, Icardi M, Dahmoush L

ANA (+) ANCA (+) systemic vasculitis associated with the use of minocycline: case-based review.

Clinical rheumatology. 2013;32(7):1099-106

Kermani TA, Ham EK, Camilleri MJ, Warrington KJ

Polyarteritis nodosa-like vasculitis in association with minocycline use: a single-center case series.

Seminars in arthritis and rheumatism. 2012;42(2):213-21

Sethi S, Sahani M, Oei LS

ANCA-positive crescentic glomerulonephritis associated with minocycline therapy.

American journal of kidney diseases : the official journal of the National Kidney Foundation. 2003;42(2):E27-31

Angulo JM, Sigal LH, Espinoza LR

Coexistent minocycline-induced systemic lupus erythematosus and autoimmune hepatitis.

Seminars in arthritis and rheumatism. 1998;28(3):187-92

Elkayam O, Levartovsky D, Brautbar C, Yaron M, Burke M, Vardinon N, Caspi D

Clinical and immunological study of 7 patients with minocycline-induced autoimmune phenomena.

The American journal of medicine. 1998;105(6):484-7

Elkayam O, Yaron M, Caspi D

Minocycline induced arthritis associated with fever, livedo reticularis, and pANCA.

Annals of the rheumatic diseases. 1996;55(10):769-71