The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.d

Alveolar hemorrhage, diffuse (ANCA-positive/-related)

Publications

Kaaroud H, Oueslati I, Harzallah A, Ben Nacef I, Khiari K, Ben Hamida F

Benzylthiouracil induced ANCA associated glomerulonephritis in patients with graves' disease.

La Tunisie medicale 2015 Nov;93;696-701 — 2015 Nov — 696-701

Sghiri R, Ouertani M, Ben Hsine H, Slim I, Chaieb L, Ghedira I

Prevalence of antineutrophil cytoplasmic antibodies during treatment with benzylthiouracil.

Pathologie-biologie 2009 Jul;57;410-4 — 2009 Jul — 410-4

Frigui M, Kechaou M, Haddouk S, Masmoudi A, Kaddour N, Masmoudi H, Turki H, Bahloul Z

[Benzylthiouracil induced ANCA-positive vasculitis: study of three cases and review of the literature].

Annales d'endocrinologie 2008 Dec;69;517-22 — 2008 Dec — 517-22

Thabet F, Sghiri R, Tabarki B, Ghedira I, Yacoub M, Essoussi AS

ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil.

European journal of pediatrics 2006 Jul;165;435-6 — 2006 Jul — 435-6