The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.m

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

Publications

Cook AV, LeRoy DI, Konja CT

A Breathtaking Case of Chemotherapy-Induced Pneumonitis.

Cureus 2025 Feb;17;e78791 — 2025 Feb — e78791

Gurjal A, An T, Valdivieso M, Kalemkerian GP

Etoposide-induced pulmonary toxicity.

Lung cancer (Amsterdam, Netherlands) 1999 Nov;26;109-12 — 1999 Nov — 109-12

Dajczman E, Srolovitz H, Kreisman H, Frank H

Fatal pulmonary toxicity following oral etoposide therapy.

Lung cancer (Amsterdam, Netherlands) 1995 Mar;12;81-6 — 1995 Mar — 81-6