The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary vasculitis or capillaritis
Publications
Phenytoin-Associated Granulomatous Pulmonary Vasculitis.
American journal of therapeutics 2016 Jan-Feb;23;e311-4 — 2016 Jan-Feb — e311-4
Necrotizing vasculitis associated with diphenylhydantoin: two fatal cases.
Human pathology 1983 Feb;14;182-4 — 1983 Feb — 182-4