The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.m

Path: Lymphoid hyperplasia (including nodular- or a lymphocytic interstitial pneumonia pattern)

Publications

Walker A, Rupal A, Jani C, Al Omari O, Singh H, Patel D, Perrino C, McCannon J

Longstanding Phenytoin Use as a Cause of Progressive Dyspnea.

Chest 2022 02;161;e91-e96 — 2022 02 — e91-e96

Swigris JJ, Berry GJ, Raffin TA, Kuschner WG

Lymphoid interstitial pneumonia: a narrative review.

Chest 2002 Dec;122;2150-64 — 2002 Dec — 2150-64

Chamberlain DW, Hyland RH, Ross DJ

Diphenylhydantoin-induced lymphocytic interstitial pneumonia.

Chest 1986 Sep;90;458-60 — 1986 Sep — 458-60