The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
ILD with a granulomatous component
BCG cane produce hypersensitivity and infectious pulmonary interstitial (and systemic) granulomas
Publications
Miliary Pneumonia as a Complication of BCG Instillation.
Deutsches Arzteblatt international 2024 Jan 26;121 — 2024 Jan 26 — 51
Miliary Tuberculosis that Developed after Intravesical Bacillus Calmette-Guerin Therapy.
Internal medicine (Tokyo, Japan) 2017;56;1563-1567 — 2017 — 1563-1567
CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 37-2015. A 76-Year-Old Man with Fevers, Leukopenia, and Pulmonary Infiltrates.
The New England journal of medicine 2015 Nov 26;373;2162-72 — 2015 Nov 26 — 2162-72
A cough conundrum in a patient with a previous history of BCG immunotherapy for bladder cancer.
BMJ case reports 2012 Oct 24;2012; — 2012 Oct 24
Hypersensitivity pneumonitis following intravesical bacille Calmette-Guérin immunotherapy for superficial bladder cancer.
Journal of investigational allergology & clinical immunology 2009;19;230-2 — 2009 — 230-2
[Miliary induced by intravesical BCG immunotherapy for carcinoma of the bladder: CT Findings].
Journal de radiologie 2002 Mar;83;368-71 — 2002 Mar — 368-71