The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIX.f

Path: ILD with a granulomatous component (see also Im)

Publications

Martos VP, Vonlanthen B

[Fatal pneumonitis during low-dose methotrexate treatment].

Zeitschrift fur Rheumatologie 2012 Jan;71;75-7 — 2012 Jan — 75-7

Imokawa S, Colby TV, Leslie KO, Helmers RA

Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients.

The European respiratory journal 2000 Feb;15;373-81 — 2000 Feb — 373-81

Sostman HD, Matthay RA, Putman CE, Smith GJ

Methotrexate-induced pneumonitis.

Medicine 1976 Sep;55;371-88 — 1976 Sep — 371-88

Lascari AD, Strano AJ, Johnson WW, Collins JG

Methotrexate-induced sudden fatal pulmonary reaction.

Cancer 1977 Oct;40;1393-7 — 1977 Oct — 1393-7