The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.e

Acute eosinophilic pneumonia (AEP)

Can cause severe ARF, necessitating MV or ECMO. If cutaneous rash present, please consider DRESS. See under specific heading

Publications

Hung SW

Minocycline-induced acute eosinophilic pneumonia: A case report and review of the literature.

Respiratory medicine case reports. 2015;15:110-4

Miller BA, Gray A, Leblanc TW, Sexton DJ, Martin AR, Slama TG

Acute eosinophilic pneumonia secondary to daptomycin: a report of three cases.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2010;50(11):e63-8

Bentur L, Bar-Kana Y, Livni E, Finkelstein R, Ben-Izhak O, Keidar S, Bentur Y

Severe minocycline-induced eosinophilic pneumonia: extrapulmonary manifestations and the use of in vitro immunoassays.

The Annals of pharmacotherapy. 1997;31(6):733-5

Liegeon MN, De Blay F, Jaeger A, Pauli G

[A cause of respiratory distress: eosinophilic pneumopathy due to minocycline].

Revue des maladies respiratoires. 1996;13(5):517-9

Sitbon O, Bidel N, Dussopt C, Azarian R, Braud ML, Lebargy F, Fourme T, de Blay F, Piard F, Camus P

Minocycline pneumonitis and eosinophilia. A report on eight patients.

Archives of internal medicine. 1994;154(14):1633-40

Yokoyama A, Mizushima Y, Suzuki H, Arai N, Kitagawa M, Yano S

Acute eosinophilic pneumonia induced by minocycline: prominent Kerley B lines as a feature of positive re-challenge test.

Japanese journal of medicine. 1990;29(2):195-8