The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: ILD with a granulomatous component (see also Im)
With BCG, granulumas can be present in several organs and tissues. See: PMID 7053820
Publications
Miliary Pneumonia as a Complication of BCG Instillation.
Deutsches Arzteblatt international 2024 Jan 26;121 — 2024 Jan 26 — 51
Miliary Tuberculosis that Developed after Intravesical Bacillus Calmette-Guerin Therapy.
Internal medicine (Tokyo, Japan) 2017;56;1563-1567 — 2017 — 1563-1567
CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 37-2015. A 76-Year-Old Man with Fevers, Leukopenia, and Pulmonary Infiltrates.
The New England journal of medicine 2015 Nov 26;373;2162-72 — 2015 Nov 26 — 2162-72
BCG-induced pneumonitis with lymphocytic pleurisy in the absence of elevated KL-6.
BMC pulmonary medicine 2014 Mar 05;14;35 — 2014 Mar 05 — 35
Miliary tuberculosis after intravesical Bacillus Calmette-Guerin immunotherapy.
Tuberkuloz ve toraks 2013;61;252-4 — 2013 — 252-4
Concurrent granulomatous hepatitis, pneumonitis and sepsis as a complication of intravesical BCG immunotherapy.
BMJ case reports 2013 Oct 10;2013; — 2013 Oct 10
Caramori G, Artioli D, Ferrara G, Cazzuffi R, Pasquini C, Libanore M, Guardigni V, Guzzinati I, Contoli M, Rossi R, Rinaldi R, Contini C, Papi A
Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 2013 Mar;79;44-8 — 2013 Mar — 44-8
Pulmonary complications of intravesicular BCG immunotherapy.
Thorax 2012 Oct;67;933-4 — 2012 Oct — 933-4
Hypersensitivity pneumonitis following intravesical bacille Calmette-Guérin immunotherapy for superficial bladder cancer.
Journal of investigational allergology & clinical immunology 2009;19;230-2 — 2009 — 230-2
Granulomatous chest disease following intravesical bacillus Calmette-Guerin immunotherapy.
Journal of thoracic imaging 2004 Jan;19;60-2 — 2004 Jan — 60-2
Diffuse alveolar damage in BCGosis: a rare complication of intravesical bacillus Calmette-Guérin therapy for transitional cell carcinoma.
Pathology 1999 Feb;31;55-6 — 1999 Feb — 55-6
Miliary tuberculosis after intravesical bacille Calmette-Guérin immunotherapy for carcinoma of the bladder.
AJR. American journal of roentgenology 1999 Mar;172;748-50 — 1999 Mar — 748-50
Disseminated infection after intravesical BCG immunotherapy. Detection of organisms in pulmonary tissue.
Chest 1993 Jul;104;307-9 — 1993 Jul — 307-9
Molecular confirmation of bacillus Calmette-Guérin as the cause of pulmonary infection following urinary tract instillation.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1993 Aug;17;228-30 — 1993 Aug — 228-30
Granulomatous pneumonitis following intravesical BCG. What therapy is needed?
Chest 1994 Nov;106;1624-6 — 1994 Nov — 1624-6
Granulomas in melanoma patients treated with BCG immunotherapy.
Cancer 1982 Jan 01;49;55-60 — 1982 Jan 01 — 55-60