The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Desquamative interstitial pneumonia (DIP-pattern)
Publications
Nitrofurantoin-induced desquamative interstitial pneumonitis in a 7-year-old child.
The Pediatric infectious disease journal 2011 Apr;30;363 — 2011 Apr — 363
Desquamative interstitial pneumonia.
Histopathology 2011 Mar;58;509-16 — 2011 Mar — 509-16
Desquamative interstitial pneumonia following chronic nitrofurantoin therapy.
Chest 1976 Feb;69;296-7 — 1976 Feb — 296-7
Desquamative interstitial pneumonia following long-term nitrofurantoin therapy.
The American journal of medicine 1976 May 10;60;697-701 — 1976 May 10 — 697-701