The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.k

Path: Desquamative interstitial pneumonia (DIP-pattern)

Publications

Hage P, El Hajje MJ

Nitrofurantoin-induced desquamative interstitial pneumonitis in a 7-year-old child.

The Pediatric infectious disease journal. 2011;30(4):363

Tazelaar HD, Wright JL, Churg A

Desquamative interstitial pneumonia.

Histopathology. 2011;58(4):509-16

Bone RC, Wolfe J, Sobonya RE, Kerby GR, Stechschulte D, Ruth WE, Welch M

Desquamative interstitial pneumonia following chronic nitrofurantoin therapy.

Chest. 1976;69(2 Suppl):296-7

Bone RC, Wolfe J, Sobonya RE, Kerby GR, Stechschulte D, Ruth WE, Welch M

Desquamative interstitial pneumonia following long-term nitrofurantoin therapy.

The American journal of medicine. 1976;60(5):697-701