The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIII.b

Lymphoproliferative disease (pulmonary, endobronchial, endothoracic)

Evidence of disease may regress upon drug withrawal (PMID 9213378)

Publications

Ichikawa S, Fukuhara N, Saito K, Onodera K, Shirai T, Onishi Y, Yokoyama H, Fujii H, Ichinohasama R, Harigae H

Successful treatment of methotrexate-associated classical Hodgkin lymphoma with brentuximab vedotin-combined chemotherapy: a case series.

International journal of hematology. 2020;111(5):667-672

Makihara S, Kariya S, Noujima-Harada M, Ohara N, Naito T, Matsumoto J, Noda Y, Okano M, Yoshino T, Nishizaki K

Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy.

Auris, nasus, larynx. 2019;46(6):927-933

Ikeue T, Kawachi H, Yoshida H, Tanaka E, Noguchi S, Fukao A, Terashita S, Tajiri T, Horikawa S, Sugita T

Endobronchial Manifestation of Methotrexate-induced Lymphoproliferative Disorder.

Internal medicine (Tokyo, Japan). 2019;58(11):1597-1603

Ujino M, Miyoshi S, Sugimoto N, Arai H, Ota Y, Sasajima Y, Kawamura M, Nagase H, Yamaguchi M, Ohta K

Methotrexate-associated Lymphoproliferative Disorder: A Rare Differential Diagnosis of Wheezes.

Internal medicine (Tokyo, Japan). 2019;58(12):1759-1764

Tsuchiya K, Suzuki Y, Yasui H, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Baba S, Suda T

Methotrexate-associated Lymphoproliferative Disorder with Diffuse Ground-Glass Opacities.

American journal of respiratory and critical care medicine. 2019;199(8):1031-1033

Lai WF, Chin YP, Liu CW, Tsai CY

Methotrexate-associated lymphoproliferative disease with multiple pulmonary nodules in a patient with rheumatoid arthritis.

BMJ case reports. 2017;2017

Kamiya Y, Toyoshima M, Suda T

Endobronchial Involvement in Methotrexate-associated Lymphoproliferative Disease.

American journal of respiratory and critical care medicine. 2016;193(11):1304-6

Tajima S, Takanashi Y, Koda K, Fukayama M

Methotrexate-associated lymphoproliferative disorder presenting as extranodal NK/T-cell lymphoma arising in the lungs.

Pathology international. 2015;65(12):661-5

Kudoh M, Harada H, Matsumoto K, Sato Y, Omura K, Ishii Y

Methotrexate-associated lymphoproliferative disorder arising in the retromolar triangle and lung of a patient with rheumatoid arthritis.

Oral surgery, oral medicine, oral pathology and oral radiology. 2014;118(4):e105-10

Yamakawa H, Yoshida M, Katagi H, Hirooka S, Okuda K, Ishikawa T, Takagi M, Kuwano K

Pulmonary and retroperitoneal lesions induced by methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis.

Modern rheumatology. 2016;26(3):441-4

Poletti V, Ravaglia C, Tomassetti S, Gurioli C, Casoni G, Asioli S, Dubini A, Piciucchi S, Chilosi M

Lymphoproliferative lung disorders: clinicopathological aspects.

European respiratory review : an official journal of the European Respiratory Society. 2013;22(130):427-36

Blanchart K, Paciencia M, Seguin A, Chantepie S, Du Cheyron D, Charbonneau P, Galateau-Salle F, Terzi N

Fatal pulmonary lymphomatoid granulomatosis in a patient taking methotrexate for rheumatoid arthritis.

Minerva anestesiologica. 2014;80(1):119-20

Wang H, Wu D, Xiang H, Chen A, Liu J

Pulmonary non-Hodgkin's lymphoma developed during long-term methotrexate therapy for rheumatoid arthritis.

Rheumatology international. 2012;32(11):3639-42

Mackie GC, Pohlen JM

Methotrexate-induced pulmonary non-Hodgkin lymphoma.

Clinical nuclear medicine. 2006;31(5):272-4

Ebeo CT, Girish MR, Byrd RP, Roy TM, Mehta JB

Methotrexate-induced pulmonary lymphoma.

Chest. 2003;123(6):2150-3

Mariette X, Cazals-Hatem D, Warszawki J, Liote F, Balandraud N, Sibilia J, Investigators of the Club Rhumatismes et Inflammation

Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France.

Blood. 2002;99(11):3909-15

Georgescu L, Quinn GC, Schwartzman S, Paget SA

Lymphoma in patients with rheumatoid arthritis: association with the disease state or methotrexate treatment.

Seminars in arthritis and rheumatism. 1997;26(6):794-804