The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LX.b

Lymphoproliferative disease (pulmonary, endobronchial, endothoracic)

Evidence of disease may regress upon drug withrawal (PMID 9213378)

Publications

Ichikawa S, Fukuhara N, Saito K, Onodera K, Shirai T, Onishi Y, Yokoyama H, Fujii H, Ichinohasama R, Harigae H

Successful treatment of methotrexate-associated classical Hodgkin lymphoma with brentuximab vedotin-combined chemotherapy: a case series.

International journal of hematology 2020 Jan 18;; — 2020 Jan 18

Makihara S, Kariya S, Noujima-Harada M, Ohara N, Naito T, Matsumoto J, Noda Y, Okano M, Yoshino T, Nishizaki K

Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy.

Auris, nasus, larynx 2019 Feb 07;; — 2019 Feb 07

Ikeue T, Kawachi H, Yoshida H, Tanaka E, Noguchi S, Fukao A, Terashita S, Tajiri T, Horikawa S, Sugita T

Endobronchial Manifestation of Methotrexate-induced Lymphoproliferative Disorder.

Internal medicine (Tokyo, Japan) 2019 Jun 01;58;1597-1603 — 2019 Jun 01 — 1597-1603

Ujino M, Miyoshi S, Sugimoto N, Arai H, Ota Y, Sasajima Y, Kawamura M, Nagase H, Yamaguchi M, Ohta K

Methotrexate-associated Lymphoproliferative Disorder: A Rare Differential Diagnosis of Wheezes.

Internal medicine (Tokyo, Japan) 2019 Jun 15;58;1759-1764 — 2019 Jun 15 — 1759-1764

Tsuchiya K, Suzuki Y, Yasui H, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Baba S, Suda T

Methotrexate-associated Lymphoproliferative Disorder with Diffuse Ground-Glass Opacities.

American journal of respiratory and critical care medicine 2019 Apr 15;199;1031-1033 — 2019 Apr 15 — 1031-1033

Lai WF, Chin YP, Liu CW, Tsai CY

Methotrexate-associated lymphoproliferative disease with multiple pulmonary nodules in a patient with rheumatoid arthritis.

BMJ case reports 2017 Dec 01;2017; — 2017 Dec 01

Kamiya Y, Toyoshima M, Suda T

Endobronchial Involvement in Methotrexate-associated Lymphoproliferative Disease.

American journal of respiratory and critical care medicine 2016 06 01;193;1304-6 — 2016 06 01 — 1304-6

Tajima S, Takanashi Y, Koda K, Fukayama M

Methotrexate-associated lymphoproliferative disorder presenting as extranodal NK/T-cell lymphoma arising in the lungs.

Pathology international 2015 Dec;65;661-5 — 2015 Dec — 661-5

Kudoh M, Harada H, Matsumoto K, Sato Y, Omura K, Ishii Y

Methotrexate-associated lymphoproliferative disorder arising in the retromolar triangle and lung of a patient with rheumatoid arthritis.

Oral surgery, oral medicine, oral pathology and oral radiology 2014 Oct;118;e105-10 — 2014 Oct — e105-10

Yamakawa H, Yoshida M, Katagi H, Hirooka S, Okuda K, Ishikawa T, Takagi M, Kuwano K

Pulmonary and retroperitoneal lesions induced by methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis.

Modern rheumatology 2016;26;441-4 — 2016 — 441-4

Poletti V, Ravaglia C, Tomassetti S, Gurioli C, Casoni G, Asioli S, Dubini A, Piciucchi S, Chilosi M

Lymphoproliferative lung disorders: clinicopathological aspects.

European respiratory review : an official journal of the European Respiratory Society 2013 Dec;22;427-36 — 2013 Dec — 427-36

Blanchart K, Paciencia M, Seguin A, Chantepie S, Du Cheyron D, Charbonneau P, Galateau-Salle F, Terzi N

Fatal pulmonary lymphomatoid granulomatosis in a patient taking methotrexate for rheumatoid arthritis.

Minerva anestesiologica 2014 Jan;80;119-20 — 2014 Jan — 119-20

Wang H, Wu D, Xiang H, Chen A, Liu J

Pulmonary non-Hodgkin's lymphoma developed during long-term methotrexate therapy for rheumatoid arthritis.

Rheumatology international 2012 Nov;32;3639-42 — 2012 Nov — 3639-42

Mackie GC, Pohlen JM

Methotrexate-induced pulmonary non-Hodgkin lymphoma.

Clinical nuclear medicine 2006 May;31;272-4 — 2006 May — 272-4

Ebeo CT, Girish MR, Byrd RP, Roy TM, Mehta JB

Methotrexate-induced pulmonary lymphoma.

Chest 2003 Jun;123;2150-3 — 2003 Jun — 2150-3

Mariette X, Cazals-Hatem D, Warszawki J, Liote F, Balandraud N, Sibilia J,

Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France.

Blood 2002 Jun 01;99;3909-15 — 2002 Jun 01 — 3909-15

Georgescu L, Quinn GC, Schwartzman S, Paget SA

Lymphoma in patients with rheumatoid arthritis: association with the disease state or methotrexate treatment.

Seminars in arthritis and rheumatism 1997 Jun;26;794-804 — 1997 Jun — 794-804