The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.f

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

Publications

Kim E, Alsamarrai A

Presumed Fatal Bronchospasm From Adenosine Administered for Assessment of Fractional Flow Reserve.

JACC. Case reports. 2026:109650

Coli S, Mantovani F, Ferro J, Gonzi G, Zardini M, Ardissino D

Adenosine-induced severe bronchospasm in a patient without pulmonary disease.

The American journal of emergency medicine. 2012;30(9):2082.e3-5

Jeng CS, Huang IR, Lin CP, Lin TY, Wang MJ

Intraoperative bronchospasm after intravenous adenosine during general anesthesia.

Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists. 2004;42(4):237-40

Aggarwal A, Farber NE, Warltier DC

Intraoperative bronchospasm caused by adenosine.

Anesthesiology. 1993;79(5):1132-5