The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Puxeddu I, Giori L, Rocchi V, Bazzichi L, Bombardieri S, Tavoni A, Migliorini P, Del Corso I

Hypersensitivity reactions during treatment with infliximab, etanercept, and adalimumab.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2012 Feb;108;123-4 — 2012 Feb — 123-4

Houtman PM, Jansen TL, Blanken R

Anaphylactic reaction in a patient with rheumatoid arthritis: a rare side effect of methotrexate with etanercept as a provoking factor?

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2006 Dec;12;321-2 — 2006 Dec — 321-2