The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Powell NR, Shugg T, Ly RC, Albany C, Radovich M, Schneider BP, Skaar TC

Life-Threatening Docetaxel Toxicity in a Patient With Reduced-Function CYP3A Variants: A Case Report.

Frontiers in oncology 2021;11;809527 — 2021 — 809527

Hettiarachchi SM, Thilakaratne D, Dharmasena D, Rathnapala A, Abeysinghe P, Perera E

Docetaxel-induced interstitial lung disease among patients with breast cancer: a case series and review of literature.

Respirology case reports 2021 Jul;9;e00802 — 2021 Jul — e00802

Gurram MK, Pulivarthi S, McGary CT

Fatal hypersensitivity pneumonitis associated with docetaxel.

Tumori 2013 May-Jun;99;e100-3 — 2013 May-Jun — e100-3

Karacan O, Eyüboglu FO, Akçay S, Ozyilkan O

Acute interstitial pneumopathy associated with docetaxel hypersensitivity.

Onkologie 2004 Dec;27;563-5 — 2004 Dec — 563-5

Read WL, Mortimer JE, Picus J

Severe interstitial pneumonitis associated with docetaxel administration.

Cancer 2002 Feb 01;94;847-53 — 2002 Feb 01 — 847-53

Wang GS, Yang KY, Perng RP

Life-threatening hypersensitivity pneumonitis induced by docetaxel (taxotere).

British journal of cancer 2001 Nov 02;85;1247-50 — 2001 Nov 02 — 1247-50

Etienne B, Pérol M, Nesme P, Vuillermoz S, Robinet G, Guérin JC

[Acute diffuse interstitial pneumopathy following docetaxel (Taxotère). Apropos of 2 cases].

Revue des maladies respiratoires 1998 Apr;15;199-203 — 1998 Apr — 199-203

Merad M, Le Cesne A, Baldeyrou P, Mesurolle B, Le Chevalier T

Docetaxel and interstitial pulmonary injury.

Annals of oncology : official journal of the European Society for Medical Oncology 1997 Feb;8;191-4 — 1997 Feb — 191-4