The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

Publications

Powell NR, Shugg T, Ly RC, Albany C, Radovich M, Schneider BP, Skaar TC

Life-Threatening Docetaxel Toxicity in a Patient With Reduced-Function CYP3A Variants: A Case Report.

Frontiers in oncology. 2021;11:809527

Hettiarachchi SM, Thilakaratne D, Dharmasena D, Rathnapala A, Abeysinghe P, Perera E

Docetaxel-induced interstitial lung disease among patients with breast cancer: a case series and review of literature.

Respirology case reports. 2021;9(7):e00802

Gurram MK, Pulivarthi S, McGary CT

Fatal hypersensitivity pneumonitis associated with docetaxel.

Tumori. 2013;99(3):e100-3

Karacan O, Eyüboglu FO, Akçay S, Ozyilkan O

Acute interstitial pneumopathy associated with docetaxel hypersensitivity.

Onkologie. 2004;27(6):563-5

Read WL, Mortimer JE, Picus J

Severe interstitial pneumonitis associated with docetaxel administration.

Cancer. 2002;94(3):847-53

Wang GS, Yang KY, Perng RP

Life-threatening hypersensitivity pneumonitis induced by docetaxel (taxotere).

British journal of cancer. 2001;85(9):1247-50

Etienne B, Pérol M, Nesme P, Vuillermoz S, Robinet G, Guérin JC

[Acute diffuse interstitial pneumopathy following docetaxel (Taxotère). Apropos of 2 cases].

Revue des maladies respiratoires. 1998;15(2):199-203

Merad M, Le Cesne A, Baldeyrou P, Mesurolle B, Le Chevalier T

Docetaxel and interstitial pulmonary injury.

Annals of oncology : official journal of the European Society for Medical Oncology. 1997;8(2):191-4