The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Alyamany R, Alnughmush A, Almutlaq M, Alyamany M, Alfayez M

Azacitidine induced lung injury: report and contemporary discussion on diagnosis and management.

Frontiers in oncology 2024;14;1345492 — 2024 — 1345492

Litvin R, Dasgupta M, Saad Eldin M, Shah M, Fakhran S

Azacitidine-Induced Pneumonitis in a Patient With Acute Myeloid Leukemia and Hyperleukocytosis.

Cureus 2022 Jul;14;e26758 — 2022 Jul — e26758

Kuroda J, Shimura Y, Mizutani S, Nagoshi H, Kiyota M, Chinen Y, Maegawa S, Kobayashi T, Matsumoto Y, Horiike S, Taniwaki M

Azacitidine-associated acute interstitial pneumonitis.

Internal medicine (Tokyo, Japan) 2014;53;1165-9 — 2014 — 1165-9

Pillai AR, Sadik W, Jones PA, Thachil J

Interstitial pneumonitis--An important differential diagnosis for pulmonary sepsis in haematology patients.

Leukemia research 2012 Jan;36;e39-40 — 2012 Jan — e39-40