The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
ARDS - Acute lung injury
Publications
Vinorelbine-induced acute respiratory distress syndrome treated with non-invasive ventilation and immunosuppressive therapy.
Respirology case reports 2018 Oct;6;e00349 — 2018 Oct — e00349
Harada H, Seto T, Igawa S, Tsuya A, Wada M, Kaira K, Naito T, Hayakawa K, Nishimura T, Masuda N, Yamamoto N
Phase I results of vinorelbine with concurrent radiotherapy in elderly patients with unresectable, locally advanced non-small-cell lung cancer: West Japan Thoracic Oncology Group (WJTOG3005-DI).
International journal of radiation oncology, biology, physics 2012 Apr 01;82;1777-82 — 2012 Apr 01 — 1777-82
Acute lung injury associated with vinorelbine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006 Apr 20;24;1952-3 — 2006 Apr 20 — 1952-3
Respiratory failure following vinorelbine tartrate infusion in a patient with non-small cell lung cancer.
Chest 1997 Sep;112;846-8 — 1997 Sep — 846-8