The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.e

Hemothorax - Serosanguineous pleural effusion

Publications

Vun SV, Lance DG

Life-threatening pleural hemorrhage following intrapleural enzyme therapy and successful treatment with fibrin-thrombin sealant pleurodesis: a case report.

Journal of medical case reports 2015 Dec 18;9;287 — 2015 Dec 18 — 287

Varnholt V, Ringe H, Nietsch L, Gaedicke G

Hemothorax under thrombolytic therapy with recombinant tissue: plasminogen activator (rt-PA) in a 16-year-old girl.

European journal of pediatrics 1999 Dec;158 Suppl 3;S140-2 — 1999 Dec — S140-2

Cafri C, Gilutz H, Ilia R, Abu-ful A, Battler A

Unusual bleeding complications of thrombolytic therapy after cardiopulmonary resuscitation. Three case reports.

Angiology 1997 Oct;48;925-8 — 1997 Oct — 925-8