The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.e

Cough (acute, violent, explosive)

Publications

Liu XS, Xu GH, Shen QY, Zhao Q, Cheng XQ, Zhang J, Gu EW

Dezocine prevents sufentanil-induced cough during general anesthesia induction: A randomized controlled trial.

Pharmacological reports : PR. 2015;67(1):52-5

Agarwal A, Gautam S, Nath SS, Gupta D, Singh U

Comparison of the incidence and severity of cough induced by sufentanil and fentanyl: a prospective, randomised, double-blind study.

Anaesthesia. 2007;62(12):1230-2

Yemen TA

Small doses of sufentanil will produce violent coughing in young children.

Anesthesiology. 1998;89(1):271-2