The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Bourgeade F, Payen M, Daigremont C, Malinovsky JM

[Respiratory depression after an accidental large dose of intrathecal sufentanil].

Annales francaises d'anesthesie et de reanimation 2009 Oct;28;903-4 — 2009 Oct — 903-4

Jaffee JB, Drease GE, Kelly T, Newman LM

Severe respiratory depression in the obstetric patient after intrathecal meperidine or sufentanil.

International journal of obstetric anesthesia 1997 Jul;6;182-4 — 1997 Jul — 182-4

Celik JB, Reisli R, Sarkilar G, Okesli S

Respiratory arrest after intrathecal injection of sufentanil and bupivacaine.

Acta anaesthesiologica Scandinavica 2004 Jul;48;793-4 — 2004 Jul — 793-4

Kehl F, Erfkamp S, Roewer N

Respiratory arrest during caesarean section after intrathecal administration of sufentanil in combination with 0.1% bupivacaine 10 ml.

Anaesthesia and intensive care 2002 Oct;30;698-9 — 2002 Oct — 698-9

Kuczkowski KM

Respiratory arrest in a parturient following intrathecal administration of fentanyl and bupivacaine as part of a combined spinal-epidural analgesia for labour.

Anaesthesia 2002 Sep;57;939-40 — 2002 Sep — 939-40

Fournier R, Gamulin Z, Van Gessel E

Respiratory depression after 5 micrograms of intrathecal sufentanil.

Anesthesia and analgesia 1998 Dec;87;1377-8 — 1998 Dec — 1377-8

Katsiris S, Williams S, Leighton BL, Halpern S

Respiratory arrest following intrathecal injection of sufentanil and bupivacaine in a parturient.

Canadian journal of anaesthesia = Journal canadien d'anesthesie 1998 Sep;45;880-3 — 1998 Sep — 880-3

Ferouz F, Norris MC, Leighton BL

Risk of respiratory arrest after intrathecal sufentanil.

Anesthesia and analgesia 1997 Nov;85;1088-90 — 1997 Nov — 1088-90

Greenhalgh CA

Respiratory arrest in a parturient following intrathecal injection of sufentanil and bupivacaine.

Anaesthesia 1996 Feb;51;173-5 — 1996 Feb — 173-5