The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Bourgeade F, Payen M, Daigremont C, Malinovsky JM

[Respiratory depression after an accidental large dose of intrathecal sufentanil].

Annales francaises d'anesthesie et de reanimation. 2009;28(10):903-4

Jaffee JB, Drease GE, Kelly T, Newman LM

Severe respiratory depression in the obstetric patient after intrathecal meperidine or sufentanil.

International journal of obstetric anesthesia. 1997;6(3):182-4

Celik JB, Reisli R, Sarkilar G, Okesli S

Respiratory arrest after intrathecal injection of sufentanil and bupivacaine.

Acta anaesthesiologica Scandinavica. 2004;48(6):793-4

Kehl F, Erfkamp S, Roewer N

Respiratory arrest during caesarean section after intrathecal administration of sufentanil in combination with 0.1% bupivacaine 10 ml.

Anaesthesia and intensive care. 2002;30(5):698-9

Kuczkowski KM

Respiratory arrest in a parturient following intrathecal administration of fentanyl and bupivacaine as part of a combined spinal-epidural analgesia for labour.

Anaesthesia. 2002;57(9):939-40

Fournier R, Gamulin Z, Van Gessel E

Respiratory depression after 5 micrograms of intrathecal sufentanil.

Anesthesia and analgesia. 1998;87(6):1377-8

Katsiris S, Williams S, Leighton BL, Halpern S

Respiratory arrest following intrathecal injection of sufentanil and bupivacaine in a parturient.

Canadian journal of anaesthesia = Journal canadien d'anesthesie. 1998;45(9):880-3

Ferouz F, Norris MC, Leighton BL

Risk of respiratory arrest after intrathecal sufentanil.

Anesthesia and analgesia. 1997;85(5):1088-90

Greenhalgh CA

Respiratory arrest in a parturient following intrathecal injection of sufentanil and bupivacaine.

Anaesthesia. 1996;51(2):173-5