The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Cough (acute, violent, explosive)
Publications
The impact of prophylactic intravenous lidocaine on opioid-induced cough: a meta-analysis of randomized controlled trials.
Journal of anesthesia 2014 Jun;28;325-33 — 2014 Jun — 325-33
The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration.
Korean journal of anesthesiology 2010 Feb;58;117-21 — 2010 Feb — 117-21
The effect of lidocaine on remifentanil-induced cough.
Anaesthesia 2008 May;63;495-8 — 2008 May — 495-8