The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Svanbom M, Rombo L, Gustafsson L

Unusual pulmonary reaction during short term prophylaxis with pyrimethamine-sulfadoxine (Fansidar).

British medical journal (Clinical research ed.). 1984;288(6434):1876

Olsen VV, Loft S, Christensen KD

Serious reactions during malaria prophylaxis with pyrimethamine-sulfadoxine.

Lancet (London, England). 1982;2(8305):994

Buser P, Räber J

[Eosinophilic lung infiltration during malaria prophylaxis with pyrimethamine-sulfadoxine (Fansidar)].

Schweizerische medizinische Wochenschrift. 1985;115(34):1174-6

McCormack D, Morgan WK

Fansidar hypersensitivity pneumonitis.

British journal of diseases of the chest. 1987;81(2):194-6

Daniel PT, Holzschuh J, Berg PA

Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar).

Thorax. 1989;44(4):307-9