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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Wu SC, Chen HS, Lin KC, Chen TI, Chang KA, Chou AK

Delayed resolution of negative pressure pulmonary edema associated with low-molecular-weight dextran after microsurgery--a case report.

Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists. 2005;43(3):187-91

Wolfenden LL, Fessler HE

A 52-year-old man with pulmonary edema following large-volume transfusion.

Chest. 2004;125(4):1556-60

Ellingson TL, Aboulafia DM

Dextran syndrome. Acute hypotension, noncardiogenic pulmonary edema, anemia, and coagulopathy following hysteroscopic surgery using 32% dextran 70.

Chest. 1997;111(2):513-8

Brandt RR, Dunn WF, Ory SJ

Dextran 70 embolization. Another cause of pulmonary hemorrhage, coagulopathy, and rhabdomyolysis.

Chest. 1993;104(2):631-3

Mangar D

Hyskon-induced pulmonary edema.

Surgery, gynecology & obstetrics. 1993;177(6):561-4

Zbella EA, Moise J, Carson SA

Noncardiogenic pulmonary edema secondary to intrauterine instillation of 32% dextran 70.

Fertility and sterility. 1985;43(3):479-80

Leake JF, Murphy AA, Zacur HA

Noncardiogenic pulmonary edema: a complication of operative hysteroscopy.

Fertility and sterility. 1987;48(3):497-9

Kaplan AI, Sabin S

Dextran 40: another cause of drug-induced noncardiogenic pulmonary edema.

Chest. 1975;68(3):376-7