The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Dimeas IE, Perlepe G, Kirgou P, McCarthy C, Daniil Z

A case of breathlessness and unexpected antibodies: stating the obvious.

Breathe (Sheffield, England) 2026 Apr;22 — 2026 Apr — 250358

Fernández AB, Karas RH, Alsheikh-Ali AA, Thompson PD

Statins and interstitial lung disease: a systematic review of the literature and of food and drug administration adverse event reports.

Chest 2008 Oct;134;824-30 — 2008 Oct — 824-30

Liscoët-Loheac N, André N, Couturaud F, Chenu E, Quiot JJ, Leroyer C

[Hypersensitivity pneumonitis in a patient taking pravastatin].

Revue des maladies respiratoires 2001 Sep;18;426-8 — 2001 Sep — 426-8

Liebhaber MI, Wright RS, Gelberg HJ, Dyer Z, Kupperman JL

Polymyalgia, hypersensitivity pneumonitis and other reactions in patients receiving HMG-CoA reductase inhibitors: a report of ten cases.

Chest 1999 Mar;115;886-9 — 1999 Mar — 886-9